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RESEARCH PROJECTS

IN PROGRESS

  1. In collaboration with the Trauma and Orthopaedics Clinical Department of the University Hospital in Kraków (manager: Dr. hab. Artur Gądek, Prof. JU: "Aplikacja kliniczna namnażanych in vitro autologicznych chondrocytów w leczeniu choroby zwyrodnieniowej kolan" [English: "Clinical application of autologous chondrocytes in the treatment of osteoarthritis of the knee"].
  2. In collaboration with the Małopolska Centre for the Treatment of Burns and Plastic Surgery of the Ludwik Rydygier Specialist Hospital in Kraków (manager: Dr. hab. Anna Chrapusta: "Zastosowanie hodowli autologicznych keratynocytów skóry ludzkiej w leczeniu oparzeń i chirurgii rekonstrukcyjnej, samodzielnie oraz z użyciem matrycy do regeneracji skóry INTEGRA oraz tłuszczopochodnych komórek mezenchymalnych" [English: "The use of autologous human skin keratinocyte cultures in the treatment of burns and reconstructive surgery, alone and with the use of the INTEGRA skin regeneration matrix and adipose-derived mesenchymal cells"].
  3. Polish Ministry of Health. Period: 2018–2021. POLISH NATIONAL PROGRAMME FOR THE DEVELOPMENT OF TRANSPLANT MEDICINE 2011–2020: "Przygotowanie do przeszczepienia autologicznych hodowanych komórek naskórka" [English: "Preparation for transplantation of autologous cultured epidermal cells", "Przygotowanie do przeszczepienia autologicznych hodowanych komórek chrząstki pobranych od żywego dawcy" [English: "Preparation for transplantation of autologous cultured cartilage cells from a living donor"].
    In total, 49 transplants of autologous keratinocytes were prepared in 2018. In total, 58 transplants of autologous keratinocytes were prepared in 2019. In total, 144 transplants of autologous keratinocytes were prepared in 2020. In total, 36 transplants of autologous keratinocytes were prepared in 2021.

COMPLETED

  1. EudraCT: 2017-004499-77: "Dwuetapowa procedura zaopatrzenia przetok odbytu powstałych w przebiegu choroby Crohna przy użyciu autologicznych tłuszczopochodnych mezenchymalnych komórek macierzystych" [English: "Two-step procedure for the treatment of anal fistulas formed in the course of Crohn's disease with the use of autologous adipose-derived mesenchymal stem cells"].
    Research phase: I/II; Number of participants: 12 Sponsor: Jagiellonian University – Medical College; Unit: Clinical Department of General Surgery with Oncology, Gabriel Narutowicz Specialist Municipal Hospital, 3rd Clinic and Department of General Surgery, Jagiellonian University – Medical College, ul. Prądnicka 35, 31-202 Kraków, Poland. Manager: Prof. Piotr Wyłęga.
  2. Polish State Committee for Scientific Research [Komitet Badań Naukowych – KBN] (PBZ-KBN-083/P05/2002). 2003–2005: "Badania nad możliwościami wykorzystania terapeutycznego nie embrionalnych komórek macierzystych u ssaków" [English: "Research into the possibilities of therapeutic use of non-embryonic stem cells in mammals], project leader: Prof. Mariusz Ratajczak.  "Izolacja, charakterystyka oraz ekspansja kliniczna komórek macierzystych naskórka" [English:  "Isolation, characteristics and clinical expansion of epidermal stem cells"], project manager: Dr. Justyna Drukała.
    Within the scope of this project, cells were prepared and transplanted to 11 patients at the Angiology Unit of 2nd Department of Internal Diseases of JU Medical College in Kraków, who were treated for trophic leg ulcers. Cultured cells were also transplanted to 7 patients at the Burns Treatment Department of the JU Medical College University Children's Hospital in Kraków, 1 patient at the West Pomeranian Centre for the Treatment of Severe Burns in Gryfice, 1 patient at the Department of Paediatric Surgery of Katowice-Ligota Hospital – treated for extensive burns; 1 patient at the Clinic of Orthopaedics and Traumatology of the Musculoskeletal System, Medical University of Warsaw – treated for an complex open fracture to the lower limb. In total, 20 treatments were performed.
  3. Polish State Committee for Scientific Research [KBN] (6 P04B 019 19). Period: 2000–2002: "Masowe hodowle komórek skóry ludzkiej w celu przyspieszenia gojenia rozległych ran oparzeniowych i przewlekłych ran troficznych z ograniczeniem bliznowacenia oraz próby rekonstrukcji trójwymiarowej skóry" [English: "Massive cultures of human skin cells to accelerate the healing of extensive burn wounds and chronic trophic wounds with reduced scarring and attempts at three-dimensional skin reconstruction"]. Manager: Dr. Kazimierz Cieślik.
    47 keratinocyte transplant treatments were performed, including to 17 patients with burns and 30 patients with trophic leg ulcers (31 patients at the Burns Treatment and Plastic Surgery Department of the Ludwik Rydygier Voivodeship Specialist Hospital in Kraków, 5 patients at the JU Medical College Department of Paediatric Surgery and 2 patients at the Burns Treatment Centre in Siemianowice Śląskie).
  4. Polish State Committee for Scientific Research [KBN] (6 P04B 927 14). Period: 1997–2000: "Zastosowanie hodowanych komórek skóry ludzkiej w klinice chirurgicznej" [English: "The use of cultured human skin cells in clinical surgery"]. Manager: Dr. Kazimierz Cieślik.
    Cultured keratinocytes were used in the treatment of 10 patients.​

  1. Polish Ministry of Science and Higher Education within the framework of the KNOW programme of the JU FBBB (35p/11/2016). Period: 2016–2017: "Aplikacja kliniczna autologicznych komórek naskórka i mezenchymalnych tłuszczopochodnych komórek macierzystych w leczeniu ran z wykorzystaniem matrycy Integra DRT" [English: "Clinical application of autologous epidermal cells and mesenchymal adipose-derived stem cells in the treatment of wounds using the Integra DRT matrix"]. Manager: Dr. hab. Justyna Drukała.
  2. Inkubator Innowacyjności 2.0 [Innovation Incubator 2.02], project No.: 13/2019: "Regeneracja ubytków tkanek miękkich przy użyciu macierzy zewnątrzkomórkowej z tkanki tłuszczowej (adipoECM)" [English: "Regeneration of soft tissue defects using the extracellular matrix of adipose tissue (adipoECM)"]. The project covers: the optimisation of methods rapid preparation of adipose tissue, and in vitro and in vivo biocompatibility tests. Manager: Dr. Marcin Piejko MD.
  3. POIG.01.01.02-00-109/09, 2009–2015. "Innowacyjne metody wykorzystania komórek macierzystych w medycynie" [English: “Innovative methods of using stem cells in medicine"] project leader: Prof. Mariusz Ratajczak. "Zbadanie roli i właściwości biologicznych komórek VSEL w regeneracji skóry” [English: "Investigation of the role and biological properties of VSEL cells in skin regeneration”], project manager: Dr. Justyna Drukała.
  4. Polish Ministry of Science and Higher Education (MNiSzW N N302 061936). Period: 2009–2012: "Aplikacja kliniczna autologicznych komórek skóry ludzkiej w leczeniu oparzeń z wykorzystaniem matrycy skóry właściwej Integra DRT – analiza procesów regeneracyjnych z wykorzystaniem modelu in vitro" [English: "Clinical application of autologous human skin cells and in the treatment of burns using the Integra DRT dermal matrix – an analysis of regenerative processes using an in vitro model"].

COLLABORATIVE RESEARCH

  1. International project 776/N-COST/2010/0; Period: 2010–2013 "Białko MCPIP w regulacji różnicowania i procesów zapalnych keratynocytów" [English: "MCPIP protein in the regulation of keratinocyte differentiation and inflammatory processes"]. Poject manager: Prof. Joalnata Jura.
  2. Polish Ministry of Science and Higher Education (MNiSzW N N301 144336). Period: 2011–2012 "Rola oksygenazy hemowej-1 w indukcji i progresji raka płaskonabłonkowego" [English: "The role of heme oxygenase-1 in the induction and progression of squamous cell carcinoma"]. Project manager: Prof. Józef Dulak.
  3. Polish State Committee for Scientific Research [KBN] (6 P04C05116) Period: 1998–2001: "Wpływ oddziaływań komórka-komórka na migrację komórek nowotworowych w kokulturach z komórkami prawidłowymi" [English: "Influence of cell-cell interactions on the migration of neoplastic cells in co-cultures with normal cells"]. Project manager: Prof.  Włodzimierz Korohoda
  4. Polish State Committee for Scientific Research [KBN] (6 P204 057 07) Period: 1995–1997: "Wpływ oddziaływań komórka-komórka na ruchy i kształt komórek w heterotypowych hodowlach in vitro" [English: "Influence of cell-cell interactions on cell movement and shape in heterotypic in vitro cultures"]. Project manager: Prof.  Włodzimierz Korohoda